Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines.
نویسندگان
چکیده
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 47 4 شماره
صفحات -
تاریخ انتشار 1999